急性脑梗死与血清、脑脊液IL1α动态变化的临床研究
脑梗死,急性；白细胞介素1α；血清；脑脊液,,脑梗死，急性；白细胞介素1α；血清；脑脊液,1资料和方法,2结果,3讨论,参考文献
【摘 要】 目的 研究炎性细胞因子白细胞介素1α(IL1α)在脑缺血性损伤方面的作用，探讨其动态变化与脑梗死的关系。方法 采用双抗体夹心酶联免疫吸附法(ELISA)测定36例脑梗死患者发病24 h、72 h、7 d血清中IL1α的含量变化，19例脑梗死患者发病24 h、7 d脑脊液中IL1α的含量变化。并与对照组20例血清、13例脑脊液IL1α水平进行比较。结果 (1)脑梗死组血清IL1α在发病24 h开始升高，且在72 h达到高峰，7 d逐渐下降，虽未达到对照组水平，但亦明显低于24 h和72 h(P<0.05或P<0.01)。(2)脑脊液IL1α在发病24 h明显升高，7 d逐渐下降，仍未达到正常对照组水平。(3)血清和脑脊液IL1α的变化呈动态正相关关系。结论 无论血清或脑脊液IL1α的持续升高可延长脑梗死的恢复期，并且预后不好。可能与缺血半暗带不能及时恢复有关。【关键词】 脑梗死，急性；白细胞介素1α；血清；脑脊液
Clinical research on the dynamic changes of serum IL1α and CSF IL1α in patients with acute cerebral infarction
LUO Yongjie,HUANG Linming，LIU Jie,et al.
Department of Neurology, The People's Hospital of Sichuan Province,Chengdu 610072,China
【Abstract】 Objective To investigate the dynamic changes of IL1α and its significance in patients with acute cerebral infarction.Methods ELISA was adopted to test the content change of IL1α in the serum of 36 patients with acute cerebral infarction (ACI) and 20 cases in the healthy control group at 24 h,72 h,as well as 7 days after the attack of the disease respectively. The content change of IL1α in the cerebrospinal fluid of 19 patients and 13 cases in control group was measured at 24h and 7days after the attack respectively.Results (1)The content of IL1α in the serum in ACI group increased at 24 h after the attack ,reaching the peak at 72 h,7 days later,it was still higher than normal level,but lower than that at 24 h and 72 h (P<0.05 or P<0.01).(2)The content of IL1α in the cerebrospinal fluid also elevated at 24h (P<0.01),and decreased at 7 days but was still higher than that of the normal level (P<0.01).(3)The changes of IL1α in the serum and the cerebrospinal fluid shows a positive correlation.Conclusion Persistent increase of either serum IL1α or cerebrospinal fluid IL1α may prolong the convalescence of patients with acute cerebral infarction and brings out a bad prognosis,might resulting from the retarded recovery of ischemic penumbra. ......
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